Preclinical and clinical evaluation of German-sourced ONC201 for the treatment of H3K27M-mutant diffuse intrinsic pontine glioma

- Duchatel, Ryan J., Mannan, Abdul, Kearney, Padraic S., Smith, Nathan D., Hindley, Kate E., Cain, Jason E., André, Nicolas, La Madrid, Andres Morales, Nixon, Brett, De Iuliis, Geoffry N., Nazarian, Javad, Irish, Kathleen, Woldu, Ameha S., Alvaro, Frank, Eisenstat, DD, Beck, A, Vitanza, NA, Mueller, S, Morris, JC, Dun, Matthew D., Hawtrey, Tom, Hindley, Phoebe A., Douglas, Alicia M., Jackson, Evangeline R., Findlay, Izac J., Germon, Zacary P., Staudt, Dilana

Shwachman-Bodian-Diamond syndrome (SBDS) protein is a direct inhibitor of protein phosphatase 2A (PP2A) activity and overexpressed in acute myeloid leukaemia

- Dun, Matthew D., Mannan, Abdul, Germon, Zacary, Faulkner, Sam, Chi, Mengna, Skerrett-Byrne, David, Murray, Heather C., Flanagan, Hayley, Almazi, Juhura G., Hondermarck, Hubert, Nixon, Brett, De Iuliis, Geoff, Rigby, Callum J., Chamberlain, J, Alvaro, F, de Bock, CE, Morris, JC, Enjeti, Anoop K., Verrills, Nicole M., Butler, Stephen, Toop, Hamish D., Beck, Dominik, Connerty, Patrick, Sillar, Jonathan, Kahl, Richard G. S., Duchatel, Ryan J.